smoking has been proven to directly cause cardiovascular disease, lung disease and lung cancer - it damages the walls of the arteries and the cells in the lining of the lungs
obesity can directly cause type 2 diabetes by making the body less sensitive or resistant to insulin, meaning that it struggles to control the concentration of glucose in the blood
drinking too much alcohol has been shown to cause liver disease. too much alcohol can affect brain function too. it can damage the nerve cells in the brain, causing the brain to lose volume
cancer can be directly caused by exposure to certain substances or radiation. things that cause cancer are known as carcinogens. ionising radiation is an example of a carcinogen