11chem

• Lewisite Metal

  Arsenic
• Component of Salvarsan/ Compound 606/ Arsphenamine (first anti-syphilis drug)

  Arsenic
• Elements and compounds are cumulative poisons

  Arsenic
• Form two series for salts:

  -____ion (As+3)→High affinity for -SH compounds in enzymes (more toxic than pentavalent arsenic)

  -____ ion (As+5)

  Arsenous ion

  Arsenic ion
• Arsenic-containing pigments:

  -_____(Cupric Aceto-arsenite)→Cu(C2H3O2)·3Cu(AsO2)2→Cupric sulfate and Arsenic trioxide

  -_____(Cupric Hydrogen Arsenite)

  Paris Green

  Scheele's Green
• Arsenic compounds and preparation

  -Arsenic Trioxide - As2O3

  -Fowler's solution

  -Donovan's solution
• Arsenious oxide, white arsenic, arsenic (III) oxide, arsenicum album

  Arsenic Trioxide - As2O3
• Amphoteric oxide

  Arsenic Trioxide - As2O3
• Therapeutic use: Antineoplastic agent, for treatment for leukemia 


  Arsenic Trioxide - As2O3
• 1% potassium arsenite solution (KAsO2)

  Fowler's Solution
• components: As2O3 and KHCO3

  Fowler's Solution
• Therapeutic use: Antileukemic, Tonic

  Fowler's Solution
• Components: AsI3 and HgI2 solution

  Donovan's solution
• Source: Antimony glance (Sb2S3), ____-____ in color


  red-orange

  -Antimony
• Pharmacologic action of water-soluble antimony compounds:


  -Astringent

  -Emetic

  -Expectorant

  -Anthelmintic for Schistosomiasis (kills and expels intestinal worms)


  Antimony
• Anthelmintic for ______ (kills and expels intestinal worms)

  Schistosomiasis
• Antimony compounds:


  -Antimony Potassium Tartrate, USP - SbKOC4H4O6
• Tartar emetic, brown mixture

  Antimony Potassium Tartrate, USP - SbKOC4H4O6
• Therapeutic use: Treatment of Schistosomiasis (liver fluke)

  Antimony Potassium Tartrate, USP - SbKOC4H4O6
• beautiful meadow

  Bismuth
• Compounds possess astringent and antiseptic action

  Bismuth
• compounds are poisonous

  Bismuth
• Therapeutic use of Bismuth compounds: _____

  Gastric protectant

  Bismuth
• S/E of Gastric protectant

  Black stools
• Antidote of Bismuth toxicity:

  Dimercaprol
• Bismuth compounds an preparations:

  -Bismuth Subnitrate, USP -Bi(OH)2NO3

  -Milk of Bismuth, USP

  -Bismuth Subsalicylate
• Basic Bismuth nitrate, bismuth oxynitrate, Spanish white, Bismuth Paint

  Bismuth Subnitrate, USP -Bi(OH)2NO3
• Therapeutic uses: Nonsystemic antacid, with astringent and antiseptic properties

  Bismuth Subnitrate, USP -Bi(OH)2NO3
• Pharmaceutic use: Excipient for preparation of Milk of Bismuth

  Bismuth Subnitrate, USP -Bi(OH)2NO3
• Bismuth cream, Bismuth magma

  Milk of Bismuth, USP
• Composition: Bismuth hydroxide and bismuth subcarbonate in suspension in water

  Milk of Bismuth, USP
• Therapeutic use: Protective for gastric ulcers, inhibit growth of H. pylori (mild antiseptic) with astringent property

  Milk of Bismuth, USP
• Therapeutic use: Antidiarrheal and mucosal protectant

  Bismuth Subsalicylate