Physiological jaunidice

• What are some causes of jaundice in the first 24 hours?

  Rhesus haemolytic disease

  ABO hameolytic disease

  Hereditary spherocytosis

  Glucose 6 phosphodehydrogenase
• Jaundice in the first 24 hours is always pathological
• Jaundice in the neonate from 2-14 days is common
• WHat causes jaundice in the neonate from 2-14 days?


  More RBCs

  More fragile RBCs

  Less developed liver function
• Who is jaundice in neonates from 2-14 days more common in?


  Breastfed babies
• What is jaundice referrred to as after 14 days (21 days if premature)?


  Prolonged jaundice
• What does a prolonged jaundice screen entail?

  Conjugated and unconjugated bilirubin

  Coomb's test

  TFTs

  FBCs

  Blood film

  Urine

  U&Es

  LFTs
• What is Coombs' test?


  Direct antiglobulin test
• What are some causes of prolonged jaundice?

  Biliary atresia

  Hypothyroidism

  Galactosaemia

  UTI

  Breast milk jaundice

  Prematurity

  Congenital infections
• Why does prematurity cause prolonged jaundice?


  Immature liver function
• What could raised conjugated bilirubin mean in prolonged jaundice?


  Biliary atresia