Chronic Kidney Disease

• Chronic Kidney Disease is the slow, sudden, irreversible loss of kidney function
• CKD Staging

  Risk or Normal - GFR of >90 ml/min
• CKD Staging

  Mild CKD - GFR of 60-90 ml/min
• CKD Staging

  Moderate CKD - GFR of 30-60 ml/min
• CKD Staging

  Severe CKD - GFR of 15-30 ml/min
• CKD Staging

  ESRD - GFR of <15 ml/min
• CKD Clinical Manifestations

  • Early CKD: Polyuria
  • Onset and the rest: Oliguria
  • GFR: low
  • BUN & Creatinine: high
  • Electrolyte: High Ka, Mg, Phosphate
  • Decreased Calcitriol: Pathologic Fractures (low calcium)
  • Acid-base: Metabolic Acidosis
  • Decreased erythropoietin: Anemia
  • Uremia - increased serum Uric Acid
  • Azotemia - increased serum Nitrogen
  • Fluid: Edema
  • Skin: Uremic Frost