IB Biology

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  • Initiation begins when the initiator tRNA carrying methionine attaches to the rRNA of the small ribosomal subunit.
    Together, they bind to the 5' end of the mRNA by recognizing the 5' cap. Then, they "walk" along the mRNA in the
    5’ to 3' direction, stopping when they reach the start codon on the mRNA (usually AUG).
    The initiator tRNA binds to the start codon of the mRNA. The large ribosomal subunit then attaches. The initiator
    tRNA sits in the P site on the ribosome. Together, the complete ribosome, the tRNA, and the mRNA are known as the initiation complex