Oral Hypoglycemic Agents

• Oral Hypoglycemic Agents

  Stimulate Islet of Langerhans to secrete Isulin
• Oral Hypoglycemic Agents

  Indicated only in Type 2 DM
• Oral Hypoglycemic Agents

  Contraindications and Drug Interactions:

  1. Aspirin, alcohol, sulfonamides, contraceptives, maois increase the hypoglycemic effect = hypoglycemia
  2. Glucocorticoids, thiazide diuretics, estrogen increase blood glucose level = hyperglycemia
  3. Sulfonylurea should not be taken with alcohol = disulfiram-like reactions
• Oral Hypoglycemic Agents

  Sulfonylureas

  • Glipizide

  Non-Sulfonylureas

  • Acarbose
  • Metformin