NMDA receptor antagonist

• Examples:

  • Memantine
• MOA:

  • Glutamate receptor antagonist
  • Increases activity of neurotransmitter glutamate
  • Glutamate is involved with learning and memory
• Route:

  • PO
• Indications:

  • Moderate to severe Alzheimer's disease
• Cautions:

  • Severe hepatic impairment
  • History of epilepsy or risk factors
• Common side effects:

  • Impaired balance
  • Constipation
  • Dizziness
  • Drowsiness
  • Hypertension
• Uncommon side effects:

  • Heart failure
  • Thrombosis
  • Confusion
  • Convulsions