The hypothalamus activates the SNS which prepares the body for fight or flight. Neurons from the SNS activate the adrenal medulla, which is part of your adrenal gland, which releases adrenaline into the bloodstream. This hormone has various effects on the pupils, heart, blood flow, lungs, digestive system and sweat glands. These changes enable the body to take action and protect itself in dangerous situations, either by running away or fighting – hence, the fight or flight response.