Alkylating Agents

• Busulfan

  A/E: Pulmonary Fibrosis (irreversible)

  • Management: Monitor result (X-ray)
• Mustargen

  A/E: Hearing Loss

  • Management: Weber and Rinne's test
• Cyclophosphamide (Cytoxan)


  A/E: Hemorrhagic Cystitis - manifested by hematuria and dysuria

  • Management: Increased OFI
• Cisplatin

  A/E: Nephrotoxicity and ototoxic

  • Management: AVOID hot and cold compress