Antimetabolites

• Antimetabolites

  Destroys cells at S phase of cell cycle
• Mercaptopurine

  A/E: Hyperuricemia

  • Management: Low purine diet
• Methotrexate

  A/E: Hepatotoxic

  • Management: Leucovorin - antidote
• Cytarabine

  A/E: Conjunctivitis

  • Management: Topical steroids
• 5FU (Fluorouracil)

  A/E: Stomatitis, Cerebellar Dysfunction

  • Management: Assess for Ataxia