Enzyme inhibitors

• Enzyme inhibitors


  molecules that slow down or stop enzyme action by decreasing the number of enzyme substrate complexes
• Competitive inhibitors

  • Similar shape to substrate
  • Binds to active site and blocks it
  • Less enzyme substrate complexes
• Non-competitive inhibitors

  • Binds to allosteric site
  • Active site changes shape
  • No longer complimentary
• Effect of competitive inhibitors


  concentration of substrate increases so it outcompetes inhibitor
• Effect of non-competitve inhibitors

  Active site changes shape so substrate can’t bind lowering rate