Paget's Disease

• Paget's Disease condition with increased rate of bone tissue breakdown (resorption) by osteoclasts followed by excessive abnormal bone formation by the osteoblasts
• Paget's Disease is also known as Osteitis Deformans
• In Paget's Disease, the diseased bone is weak and prone to fracture
• Paget's Disease Clinical Manifestations:

  • Bone pain
  • Bone deformity
  • Nerve compression
  • Pathologic fractures
  • Blindness and hearing loss due to involvement of the cranium
• Paget's Disease Management:

  • NSAIDS - for pain
  • Calcitonin / Etidronate - to retard bone absorption
  • Plicamycin (Cytotoxic Antibiotic) - to decrease serum Calcium, hydroxyproline, serum alkaline phosphatase