feline diffuse iris melanoma presents unilaterally with Hyperpigmented iris spot(s), usually progressing to diffuse hyperpigmentation of whole iris +/- abnormalities in pupil shape +/- uveitis/glaucoma. this can be suspected from the clinical appearance but histopathology provides a definitive diagnosis. treatment is ideally enucleation (+ histopathology) but the prognosis is guarded due to the high risk of metastasis