genetic explanation for schizophrenia

    Cards (19)

    • What does the explanation suggest about the inheritance of schizophrenia?
      Schizophrenia is passed on through our genes.
    • How does genetic similarity relate to the risk of developing schizophrenia?
      The risk of schizophrenia increases with genetic similarity to a relative with the condition.
    • What was the general population rate of schizophrenia found by Gottesman (1991)?
      1%
    • What is the chance of developing schizophrenia if someone has an aunt with the condition?

      2%
    • What is the chance of developing schizophrenia if someone has a sibling with the condition?
      9%
    • What is the chance of developing schizophrenia if someone has an identical twin with the condition?
      48%
    • What do psychologists compare to investigate the genetic links of schizophrenia?
      They compare the concordance rate of schizophrenia in identical and non-identical twins.
    • What does a higher concordance rate in identical twins suggest about schizophrenia?
      It suggests that genes play an important role in the development of schizophrenia.
    • What does research suggest about the genetic nature of schizophrenia?
      Schizophrenia is polygenic.
    • What did Ripke et al (2014) study reveal about genetic variations related to schizophrenia?
      108 genetic variations were found to be associated with an increased risk of schizophrenia.
    • What does it mean that schizophrenia is aetiologically heterogeneous?
      It means many different combinations of factors, including genetic variation, can lead to the condition.
    • How can genetic mutations contribute to the development of schizophrenia?
      If parental DNA mutates, an individual may become genetically predisposed to schizophrenia.
    • What correlation exists between paternal age and the risk of schizophrenia?
      There is a positive correlation between paternal age and the risk of schizophrenia.
    • What is the average risk of schizophrenia when a father is under 25 years old?
      0.7%
    • What is the average risk of schizophrenia when a father is over the age of 50?
      2%
    • What role do family studies play in understanding the genetic links to schizophrenia?
      Family studies confirm that the risk of schizophrenia increases with genetic similarity.
    • Why are concordance rates in twin studies significant for understanding schizophrenia?
      They help determine the influence of genetics versus environment in the disorder's development.
    • What are the implications of schizophrenia being polygenic for treatment and research?
      It suggests that multiple genetic factors need to be considered in treatment and research.
    • How does paternal age impact genetic mutations related to schizophrenia?
      Older paternal age is associated with a higher risk of genetic mutations that may lead to schizophrenia.