2. Thrombosis

• What is thrombosis?

  Blood clotting to prevent blood loss
• What triggers the conversion of prothrombin to thrombin?

  Thromboplastin released from platelets
• What is the role of fibrin in blood clotting?

  It forms a network trapping platelets and cells
• Explain the stages of thrombosis

  Thromboplastin

  
• What reaction does thromboplastin catalyse in the blood clotting cascade?

  Prothrombin to Thrombin
• What ion and mineral is necessary for blood clotting?

  Calcium ions and Vitamin K
• Is fibrin soluble or insoluble?

  Insoluble
• What effect does insoluble fibrin have on other platelets and RBCs?

  Get trapped and form blood clot mesh
• Why does blood need to clot  

  Seal a break in the blood vessel
• What are the benefits of blood clotting

  • Limit blood loss
  • Prevents entry of pathogens
• Coronary heart disease

  Is when the coronary arteries have a lot of arthromas in them, which restricts blood flow to the heart. the atheromas also increase the risk of clots,  leading to an increased risk of heart attack  
• Stroke

  Is the Rapid loss of brain function due to a disruption in the blood supply to the brain this can be caused by a blood clot in the artery which reduces the amount of blood and therefore oxygen that can reach the brain     
• Deep vein thrombosis

  Is a formation of a blood clot in a vein deep inside the body- it usually happens in a leg vein it can be caused by prolonged inactivity (for example during long haul flights and the risk increases with age)