CTS/2/cell membrane & transport

Cards (316)

  • What provides the basic structure for all cell membranes?
    The lipid bilayer
  • Why is the lipid bilayer easily seen by electron microscopy?
    Due to its distinct bilayer structure
  • What property allows lipid molecules to assemble into bilayers spontaneously?
    The special properties of lipid molecules
  • What are the general properties of lipid bilayers?
    • Composed of lipid molecules
    • Amphiphilic nature
    • Fluidity allows movement
    • Self-sealing property
  • What characteristic do all lipid molecules in cell membranes share?
    They are amphiphilic
  • What are the two ends of amphiphilic lipid molecules?
    Hydrophilic and hydrophobic ends
  • What are the most abundant membrane lipids?
    Phospholipids
  • What do phospholipids consist of?
    A polar head group and two hydrophobic tails
  • What influences the fluidity of the membrane in phospholipids?
    Length and saturation of fatty acid tails
  • What is the main type of phospholipid in most animal cell membranes?
    Glycerophospholipids
  • What is the structure of glycerophospholipids?
    Three-carbon glycerol backbone with fatty acids
  • What are the most abundant glycerophospholipids in mammalian cell membranes?
    Phosphatidylethanolamine, phosphatidylserine, phosphatidylcholine
  • What distinguishes sphingolipids from glycerophospholipids?
    Sphingolipids are built from sphingosine
  • What is the most common sphingolipid?
    Sphingomyelin
  • What do glycolipids resemble?
    Sphingolipids
  • What is the primary sterol found in animal cells?
    Cholesterol
  • How do cholesterol molecules orient themselves in the bilayer?
    With their hydroxyl group near polar heads
  • What drives phospholipids to form bilayers in aqueous environments?
    The shape and amphiphilic nature of phospholipids
  • What happens to hydrophilic molecules in water?
    They dissolve readily
  • Why are hydrophobic molecules insoluble in water?
    They are uncharged and nonpolar
  • What is the entropic free-energy cost associated with hydrophobic molecules in water?
    Increased free energy due to ordered water cages
  • How do phospholipid molecules behave in an aqueous environment?
    They pack to minimize hydrophobic tail exposure
  • What are the two optimal packing arrangements for phospholipids?
    Spherical micelles and double-layered bilayers
  • What property allows a bilayer to self-seal?
    The prohibition of free edges
  • Why is fluidity important for cell membranes?
    It is crucial for many membrane functions
  • What did researchers discover about lipid molecules in the bilayer around 1970?
    They can diffuse freely within the bilayer
  • What is the process called when lipid molecules migrate from one monolayer to another?
    Flip-flop
  • How long does it take for a lipid molecule to diffuse the length of a large bacterial cell?
    About 1 second
  • What do computer simulations show about lipid molecules in synthetic bilayers?
    They present an irregular, ragged surface
  • What do mobility studies on biological membranes reveal?
    They are two-dimensional liquids
  • What problem arises for the growth of biological membranes?
    Asymmetrical expansion of the membrane
  • How do phospholipid translocators solve the problem of membrane growth?
    They catalyze rapid flip-flop of phospholipids
  • Why do liposomes not fuse spontaneously in water?
    Due to the hydration shell around lipids
  • What prevents uncontrolled fusion of internal membranes in eukaryotic cells?
    The hydration shell around biological membranes
  • What regulates the fluidity of cell membranes?
    The composition and temperature of the bilayer
  • What is a phase transition in lipid bilayers?
    Change from liquid state to rigid crystalline state
  • What effect do shorter hydrocarbon chains have on membrane fluidity?
    They reduce the tendency to interact
  • How do cis-double bonds affect membrane fluidity?
    They create kinks that prevent packing
  • How do organisms maintain constant membrane fluidity with temperature changes?
    By adjusting fatty acid composition
  • What role do sterols play in lipid bilayers?
    They enhance permeability-barrier properties