Nucleus: Prokaryotic - not present; Eukaryotic - present
DNA: Prokaryotic - circular; Eukaryotic - linear
DNA organization: Prokaryotic - not associated with histones; Eukaryotic - associated with histones
Organelles: Prokaryotic - non-membrane bound; Eukaryotic - membrane-bound
Ribosomes: Prokaryotic - smaller (70s); Eukaryotic - larger (80s)
Cytoskeleton: Prokaryotic - present; Eukaryotic - present and more complex
Reproduction: Prokaryotic - binary fission; Eukaryotic - asexual or sexual
Cell type: Prokaryotic - unicellular; Eukaryotic - unicellular and multicellular
Cell surface membrane: Present in both