Cell mediated immunity

• What do T-cells respond to in relation to where antigens are?

  Antigens that are presented on a body cell (rather than to antigens within the bodily fluids?
• Where are T-lymphocytes made?

  Bone marrow
• Where are T-lymphocytes matured?

  The thymus gland.
• How many different antigens do the receptors on T-cells respond to?

  1
• What is stage one in cell mediated immunity?

  Pathogens invade body cells or are taken in by phagocytes.
• What is stage two in cell mediated immunity?

  The phagocyte places antigens from the pathogen on it's cell-surface membrane- antigen-presenting cells.
• What is stage three in cell mediated immunity?

  Receptors on a specific helper T cell fit exactly onto these antigens, this activates them.
• What is stage four of cell mediated immunity?

  This attachment activates the T cell to divide rapidly by mitosis and form a clone of genetically identical cells.
• What is stage five of cell mediated immunity?

  The cloned T cells develop into memory cells, stimulate phagocytosis, stimilate B cells or activate cytotoxic T cells.
• How do cytotoxic T-cells kill infected cells?

  They produce a protein called perforin that makes holes in the cell surface membrane. The holes mean the cell membrane becomes freely permeable to all substances and the cell dies as a result.