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psc3013 lectures 11-14
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Cards (14)
What is mucus primarily composed of?
Water,
glycoproteins
, and electrolytes
What is the role of glycoproteins in mucus?
They create a
viscoelastic
barrier trapping
pathogens
How does
mucus
protect
mucosal
surfaces?
It lubricates and protects from damage
What is the significance of mucosal protection?
It prevents
pathogens
from reaching
underlying
cells
What are the physical properties of mucus?
Viscosity
, elasticity, hydration,
glycoproteins
, water,
electrolytes
What are endogenous aggressors?
Internal factors damaging the
gastric mucosa
How do
endogenous aggressors
differ from external factors?
Endogenous aggressors are produced internally
What are the main endogenous aggressors to the gastric mucosa?
Acid
Pepsin
Biliary reflux
What is the role of acid in the stomach?
It aids
digestion
and kills
bacteria
What pH range characterizes gastric acid?
5-3.5
What can happen if acid is not balanced by protective mechanisms?
It can damage the gastric mucosa
Under what condition does pepsin damage the gastric mucosa?
If mucus protection is insufficient
What is biliary reflux?
Backflow of bile into the stomach
How do bile acids damage the gastric mucosa?
They disrupt the protective mucus layer
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