Induced fit hypothesis

• define induced fit hypothesis

  -enzyme slightly changes shape as substrate enters
• Outline the first interactions that occur in induced fit hypothesis

  -initial interaction between enzyme and substrate is weak
• What ,however, do these weak interactions do?

  -rapidly induce changes in the enzymes tertiary structure that strengthen binding putting strain on the substrate molecule
• This can...

  -weaken a particular bond in substrate therefore lowering activation energy