Pharm formulations WK1

• What are the classifications of dosage forms based on route of administration?

  • Oral
  • Parenteral
  • Topical/Transdermal
  • Ophthalmic/Ocular
  • Otic
  • Respiratory
  • Rectal
  • Vaginal
• What are the classifications of dosage forms based on physical form?

  • Solid: Tablets, Capsules, Powders, Granules
  • Liquid: Solutions, Suspensions
  • Semi-solid: Ointment, Cream, Gel
  • Gas: Inhalers, Aerosols
• What is the first stage of the drug discovery process?

  Pre-formulation
• What is assessed during the pre-formulation stage?

  Key properties of the API
• What must all APIs have for therapeutic effect?

  Some aqueous solubility
• What are some physico-chemical properties studied in pre-formulation?

  Stability, solubility, crystal form
• What considerations are taken into account during the formulation stage?

  • Target population
  • Route of administration
  • Formulation type, dose, regimen
  • Stability/Shelf life
  • Means of manufacture