biological explanations

Cards (21)

  • What is the genetic explanation for schizophrenia (SZ)?
    Individuals inherit a genetic vulnerability
  • What does it mean that SZ is polygenic?
    Multiple genes are involved affecting dopamine
  • How many different genes did Ripke et al find involved in SZ?
    108 different genes
  • What does aetiologically heterogeneous mean in the context of SZ?
    Different combinations of factors can lead to SZ
  • Can SZ occur without a family history of the disorder?
    Yes, due to radiation, poison, or viral infection
  • How does the risk of developing SZ change with age for men?
    Risk triples if over 50 years old
  • What is the chance of developing SZ if a man is under 25?
    0.7%
  • What is the chance of developing SZ if a man is over 50?
    2%
  • What was the original dopamine hypothesis based on?
    Discovery of antipsychotics causing Parkinson's-like symptoms
  • How does the original dopamine hypothesis relate schizophrenia to dopamine levels?
    Schizophrenia may result from high dopamine levels
  • What does 'hyperdopaminergia' mean?
    High levels of dopamine in the brain
  • Which brain area is associated with speech production in schizophrenia?
    Broca's area
  • How might excess dopamine receptors affect speech in schizophrenia?
    They may cause poverty of speech and hallucinations
  • Who proposed the updated versions of the dopamine hypothesis?
    Kenneth Davis et al.
  • What is cortical hypodopaminergia?
    Abnormally low dopamine in the brain's cortex
  • How can low dopamine in the prefrontal cortex affect schizophrenia symptoms?
    It could explain cognitive problems and negative symptoms
  • What relationship is suggested between cortical hypodopaminergia and subcortical hyperdopaminergia?
    Cortical hypodopaminergia leads to subcortical hyperdopaminergia
  • What do current versions of the dopamine hypothesis aim to explain?
    Links between abnormal dopamine levels and symptoms
  • What factors contribute to abnormal dopamine function according to current hypotheses?
    Genetic variations and early stress experiences
  • How do early experiences of stress affect dopamine sensitivity?
    They make some people more sensitive to dopamine changes
  • What is the significance of Howes et al. (2017) in the context of dopamine hypothesis?
    They discussed stress and genetic variations' effects