Drug Absorption

    Cards (26)

    • What is drug absorption?
      Movement of a drug into the blood
    • How does drug absorption influence drug effectiveness?
      It affects how well the drug works
    • What does the rate of absorption influence?
      How quickly a drug can have effects
    • Why is quick absorption important for headache relief?
      To reduce pain levels rapidly
    • What happens if there is little drug absorption?
      Not much of the dose reaches the blood
    • What is the therapeutic range?
      Range of drug concentration for effectiveness
    • What are the factors affecting drug absorption?
      • Lipid solubility
      • Activity of drug transporters
      • Drug ionization
      • Gastric emptying
    • How does lipid solubility affect drug absorption?
      More lipophilic drugs cross membranes easily
    • Why do hydrophilic drugs need transport proteins?
      To improve their absorption into cells
    • What is the role of uptake transporters?
      They move drugs into cells
    • What do efflux transporters do?
      They decrease drug absorption by moving drugs out
    • How does drug ionization affect absorption?
      Ionized drugs are less lipophilic and absorb poorly
    • Where is the optimal site of absorption for oral medications?
      Small intestine
    • Why is the stomach not ideal for drug absorption?
      It has a thick mucus layer and low pH
    • What factors affect gastric emptying?
      Consistency of food, meal composition, body position
    • How does liquid consistency affect gastric emptying?
      Liquids move faster than solid foods
    • How does a fatty meal affect gastric emptying?
      It slows down stomach motility
    • How does body position influence gastric emptying?
      Sitting or standing increases gastric emptying
    • Why does lying on the right side affect gastric emptying?
      Pyloric sphincter is oriented to the right
    • How can other medications affect gastric emptying?
      They can change the rate of absorption
    • What effect do opioids have on GI motility?
      They inhibit GI motility
    • Why might a weak acid be absorbed more efficiently in the stomach?
      Stomach has a low pH, favoring non-ionization
    • Why are oral drugs, including weak acids, absorbed in the small intestine?
      Small intestine has a larger surface area
    • How does the amount of drug absorption affect its effects?
      More absorption leads to more intense effects
    • How does the speed of absorption influence drug action?
      Faster absorption leads to quicker effects
    • What is the relationship between drug absorption and the therapeutic window?
      • More absorption increases drug concentration in blood
      • Faster absorption leads to quicker therapeutic effects
      • Therapeutic window defines effective drug concentration range
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