Chronic Inflammation and Healing

• what is healing

  how we replace necrotic tissue
• what is resolution 


  complete return to normal structure and function
• what is repair 


  replacement of dead tissue by scar tissue
• what does healing depend on

  type of tissue involved and extent of tissue damage
• what is resolution regarding acute inflammation 


  ideal outcome
• when does resolution occur

  -if surviving cells can undergo regeneration

  -tissue damage is limited
• what happens in resolution

  -complete removal of all cells, by products and exudates

  -microcirculation returns to its pre-inflammatory state
• In resolution how is dead tissue cells and fibrin removed

  macrophages
• In resolution how is inflammatory exudate removed

  lymphatic system
• when does repair happen

  -when complete return of tissue to normal is not possible

  -extensive tissue damage

  -cells cannot regenerate