First & Second line of defence

Cards (57)

  • What is the first category of defense methods?
    Physical
  • What do physical defenses do?
    Prevent the entry of pathogens
  • What is the second category of defense methods?
    Cellular
  • What do cellular defenses do?
    Detect and signal pathogens
  • What is the third category of defense methods?
    Chemical
  • What do chemical defenses generate?
    An inhospitable environment for pathogens
  • What is the fourth category of defense methods?
    Commensal organisms
  • How do commensal organisms help the body?
    Compete with pathogens for nutrients
  • What is the first line of defense in humans?
    Prevents entry of pathogens
  • What comprises the first line of defense?
    Skin, mucous membranes, expulsive reflexes, chemical secretions
  • What is the outer layer of skin made of?
    Dry, dead, hardened cells
  • What protein fills the outer layer of skin cells?
    Keratin
  • How does the skin act as a barrier to pathogens?
    By being a physical barrier
  • What do secretions of sebum contain?
    Fatty acids with antimicrobial properties
  • What does the evaporation of sweat leave behind?
    A salt residue
  • How does low moisture and high salinity affect microorganisms?
    Creates an inhospitable environment
  • Where do mucous membranes line?
    The gut, airways, and reproductive system
  • What do goblet cells secrete?
    Mucus
  • What makes mucus sticky?
    Glycoproteins with long carbohydrate chains
  • What can mucus in the airways trap?
    Viruses, bacteria, pollen, and dust
  • How are trapped particles moved in the airways?
    By cilia
  • What are cilia?
    Small hair-like structures on cells
  • What triggers an expulsive reflex?
    Irritation of the airway lining
  • What do coughs and sneezes expel?
    Air containing secretions and particles
  • What are lysozymes?
    Antimicrobial enzymes
  • Where are lysozymes found?
    In body fluids like blood and tears
  • What does hydrochloric acid do in the stomach?
    Kills ingested bacteria
  • How do gut cells protect themselves from hydrochloric acid?
    By secreting mucus
  • How much of a human's weight is made up of bacteria?
    Roughly 1 kg
  • Where do commensal microorganisms grow?
    On the skin, in the mouth, and intestines
  • How do commensal microorganisms benefit humans?
    By preventing pathogen invasion
  • What can happen when antibiotics kill friendly gut bacteria?
    Opportunistic pathogens can grow
  • What happens when the first line of defense is evaded?
    The second line of defense responds
  • What does the second line of defense involve?
    Phagocytic cells and antimicrobial proteins
  • What are some responses included in the second line of defense?
    Blood clotting, inflammation, wound repair, phagocytosis
  • What triggers blood clotting when the body is wounded?
    A break in mucous or skin membranes
  • What do platelets release during blood clotting?
    Substances that trigger chemical reactions
  • What is the end product of blood clotting?
    Fibrin forms a network
  • What does blood clotting prevent?
    Excess blood loss and pathogen entry
  • What is inflammation?
    A local response to infection and tissue damage