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Communicable Disease
Non-Specific Immune Response
First & Second line of defence
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Melodi
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Cards (57)
What is the first category of defense methods?
Physical
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What do physical defenses do?
Prevent the entry of
pathogens
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What is the second category of defense methods?
Cellular
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What do cellular defenses do?
Detect and signal
pathogens
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What is the third category of defense methods?
Chemical
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What do chemical defenses generate?
An inhospitable environment for
pathogens
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What is the fourth category of defense methods?
Commensal organisms
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How do commensal organisms help the body?
Compete with
pathogens
for nutrients
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What is the first line of defense in humans?
Prevents entry of
pathogens
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What comprises the first line of defense?
Skin
,
mucous membranes
, expulsive reflexes, chemical secretions
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What is the outer layer of skin made of?
Dry,
dead
, hardened cells
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What protein fills the outer layer of skin cells?
Keratin
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How does the skin act as a barrier to pathogens?
By being a
physical
barrier
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What do secretions of sebum contain?
Fatty acids with
antimicrobial
properties
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What does the evaporation of sweat leave behind?
A
salt residue
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How does low moisture and high salinity affect microorganisms?
Creates an
inhospitable
environment
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Where do mucous membranes line?
The
gut
,
airways
, and
reproductive system
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What do goblet cells secrete?
Mucus
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What makes mucus sticky?
Glycoproteins
with long
carbohydrate
chains
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What can mucus in the airways trap?
Viruses
,
bacteria
,
pollen
, and
dust
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How are trapped particles moved in the airways?
By
cilia
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What are cilia?
Small hair-like structures on
cells
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What triggers an expulsive reflex?
Irritation of the
airway lining
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What do coughs and sneezes expel?
Air containing
secretions
and particles
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What are lysozymes?
Antimicrobial
enzymes
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Where are lysozymes found?
In body fluids like
blood
and
tears
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What does hydrochloric acid do in the stomach?
Kills
ingested
bacteria
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How do gut cells protect themselves from hydrochloric acid?
By secreting
mucus
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How much of a human's weight is made up of bacteria?
Roughly
1 kg
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Where do commensal microorganisms grow?
On the
skin
, in the mouth, and intestines
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How do commensal microorganisms benefit humans?
By preventing
pathogen
invasion
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What can happen when antibiotics kill friendly gut bacteria?
Opportunistic pathogens
can grow
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What happens when the first line of defense is evaded?
The
second line of defense
responds
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What does the second line of defense involve?
Phagocytic cells
and
antimicrobial proteins
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What are some responses included in the second line of defense?
Blood clotting
, inflammation, wound repair,
phagocytosis
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What triggers blood clotting when the body is wounded?
A break in
mucous
or skin
membranes
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What do platelets release during blood clotting?
Substances that trigger
chemical reactions
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What is the end product of blood clotting?
Fibrin
forms a network
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What does blood clotting prevent?
Excess blood loss and
pathogen
entry
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What is inflammation?
A local response to
infection
and tissue damage
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