Candidate genes

• Schizophrenia is polygenic
• What does it mean if schizophrenia is polygenic?

  Multiple genes involved
• Schizophrenia is also aetiologically heterogenous
• Who combined previous data from genome-wide studies of Schizophrenia?

  Ripke
• How many patients did Ripke look at?

  37,000
• How many controls did Ripke look at?

  113,000
• What was the ratio of patients to control in Ripke's study?

  37,000:113,000
• What did Ripke find?

  108 genetic variations associated with increased risk
• What is an explanation for the genetic origin of schizophrenia with no family history?

  Mutation
• What does it mean if schizophrenia is aetiologically heterogenous?

  Combination of different factors
• What would the most likely genes for schizophrenia be?

  Those coding for neurotransmitters