If a stressor is sensed, the hypothalamus activates the pituitary gland, shifting the ANS from the parasympathetic state to the sympathetic state, causing adrenaline release from the adrenal medulla, & increasing heart rate to trigger the fight-or-flight response. This occurs fast, causing physical changes like 'butterflies' in the stomach. After the threat passes, the parasympathetic nervous system counteracts the sympathetic response, returning the body to resting state: the rest and digest response.