Large body of evidence to support the effectiveness of CBT - March compared the effects of CBT with antidepressant drugs and a combination of the two in 327 adolescents with a main diagnosis of depression. After 36 weeks 81% of the CBT group, 81% of the antidepressants group and 86% of the CBT plus antidepressants group were significantly improved so CBT emerged as just as effective as medication and helpful alongside medication