A03

• What neurotransmitter is suggested to be involved in schizophrenia?

  Dopamine (DA)
• How do amphetamines affect dopamine levels in schizophrenia?

  They increase DA and worsen symptoms
• What effect do antipsychotic drugs have on dopamine activity?

  They reduce DA activity and symptoms
• What do candidate genes related to schizophrenia affect?

  Production of dopamine or DA receptors
• What does the evidence suggest about dopamine's role in schizophrenia?

  Dopamine is strongly involved in symptoms
• What neurotransmitter is highlighted as a limitation to the dopamine hypothesis?

  Glutamate
• What have studies found about glutamate levels in schizophrenia?

  Raised levels in several brain regions
• What is suggested about candidate genes in relation to glutamate?

  They are involved in glutamate production or processing
• What conclusion can be drawn about neurotransmitters in schizophrenia?

  Other neurotransmitters may also play a role