Stroke 3

• What is the PICO framework?

  Population

  Intervention

  Comparison

  Outcome

  
• How can we minimise selection bias?

  Random assignment of intervention & control treatments

  Allocation concealment

  Efforts to minimise loss to follow-up
• How can we minimise information bias?

  Blinding

  Standardised procedures for collecting/measuring outcomes
• What is internal vs external validity?

  Internal = a valid estimate of treatment effect in THIS SAMPLE

  External = generalisability
• NOTE: To judge external validity one has to have a population/individual patient/setting in mind
• Fill in the blanks

  A) Case reports

  B) Cross sectional study

  C) Qualitative study

  D) Case-control study

  E) Cohort study

  F) Randomised control trial

  G) Systematic review

  H) Meta-analysis

  
• What is a better method; intention to treat (changing doses of meds as pt needs) or per-protocol (same dose no matter what)?

  Intention to treat

  -> this mimics what happens in practice