Multiple myeloma

• What is multiple myeloma?

  Plasma cell disorder and bone marrow infiltration by plasma cells (mature antibody producing B cells)
• What are some symptoms of multiple myeloma?

  Fever

  Fatigue

  Weight loss

  CRABBI
• What does CRABBI stand for?

  Calcium high

  Renal impairment

  Anaemia

  Bleeding

  Bone pain/fracture

  Infection
• What sex is multiple myeloma common in?

  Male
• What are some risk factors for multiple myeloma?

  Age (older)

  Sex

  African

  Family history

  Obesity
• What blood tests are done for multiple myeloma?

  FBC

  U&Es

  Bone profile

  Plasma viscosity

  Serum protein electrophoresis

  Peripheral blood film (Rouleaux formation)
• What scans are done for multiple myeloma?

  Full body MRI

  X-ray (rain-drop skull)

  Bone marrow aspiration
• What are some surgical treatments for multiple myeloma?

  Stem cell transplant

  Orthopaedic surgery for bone lesions
• What are some medical treatments for medical myeloma?

  Radiotherapy

  Chemotherapy

  Bisphosphonates
• What chemotherapy is given for multiple myeloma?

  Dex

  Bortezomib

  Thalidomide
• What could a painless, asymmetrical lymph node swelling in the neck?

  Multiple myeloma