dopamine hypothesis

• What is dopamine classified as?

  Neurotransmitter
• What does the dopamine hypothesis of schizophrenia suggest?

  Dopamine system abnormalities cause schizophrenia
• What is hyperdopaminergia?

  Increased dopamine activity
• Where in the brain is hyperdopaminergia linked to positive symptoms of schizophrenia?

  Subcortex
• How do high levels of D2 receptors affect dopamine binding?

  They increase dopamine binding and neuron firing
• What area of the brain, when affected by increased dopamine activity, can lead to auditory hallucinations?

  Broca’s area
• What are symptoms of paranoid and disorganized schizophrenia?

  Auditory hallucinations and word salad
• What is hypodopaminergia?

  Decreased dopamine activity
• In which part of the brain is hypodopaminergia linked to negative symptoms of schizophrenia?

  Cortex
• What cognitive deficits can decreased activity in the prefrontal cortex lead to?

  Avolition and impaired decision making
• How does decreased dopamine activity in the prefrontal cortex affect schizophrenia symptoms?

  It leads to negative symptoms like avolition
• What functions are associated with dopamine in the brain?

  Movement and attention
• What symptoms are linked to increased dopamine activity in schizophrenia?

  Positive symptoms like hallucinations
• What is the role of the prefrontal cortex in schizophrenia?

  Responsible for higher-order thinking