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Treatment
Morphine
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Created by
Jessica Jardine
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Cards (7)
Why does only a small percentage of morphine enter the BBB?
Morphine
is
least lipophilic
of
common opioids
So cannot
cross BBB
as well
What is morphine?
Opiate analgesic
What is the pharmacology of morphine?
Primary target =
mu receptor
Primary target =
full agonist
Secondary target =
kappa receptor
Secondary action =
partial agonist
Secondary target =
delta receptor
Secondary action =
full agonist
What does morphine do?
Decreases
AP
generation
Decreases
ascending
pain
pathway
Increases
descending
inhibition
pathway
What is the indication for morphine?
Pain relief
What are the desired effects of morphine?
Analgesia
Anti-diarrhoeal
Sedation
What are the adverse effects of morphine?
Respiratory depression
Nausea
/
vomiting
Constipation
Addiction