Morphine

• Why does only a small percentage of morphine enter the BBB?

  Morphine is least lipophilic of common opioids

  So cannot cross BBB as well
• What is morphine?

  Opiate analgesic
• What is the pharmacology of morphine?

  Primary target = mu receptor

  Primary target = full agonist

  Secondary target = kappa receptor

  Secondary action = partial agonist

  Secondary target = delta receptor

  Secondary action = full agonist
• What does morphine do?

  Decreases AP generation

  Decreases ascending pain pathway

  Increases descending inhibition pathway
• What is the indication for morphine?

  Pain relief
• What are the desired effects of morphine?

  Analgesia

  Anti-diarrhoeal

  Sedation
• What are the adverse effects of morphine?

  Respiratory depression

  Nausea/vomiting

  Constipation

  Addiction