Morphine

Cards (7)

  • Why does only a small percentage of morphine enter the BBB?
    Morphine is least lipophilic of common opioids
    So cannot cross BBB as well
  • What is morphine?
    Opiate analgesic
  • What is the pharmacology of morphine?
    Primary target = mu receptor
    Primary target = full agonist
    Secondary target = kappa receptor
    Secondary action = partial agonist
    Secondary target = delta receptor
    Secondary action = full agonist
  • What does morphine do?
    Decreases AP generation
    Decreases ascending pain pathway
    Increases descending inhibition pathway
  • What is the indication for morphine?
    Pain relief
  • What are the desired effects of morphine?
    Analgesia
    Anti-diarrhoeal
    Sedation
  • What are the adverse effects of morphine?
    Respiratory depression
    Nausea/vomiting
    Constipation
    Addiction