Digestion of proteins

• What is the role of endopeptidase in the digestion of proteins?

  Endopeptidase hydrolyses peptide bonds in the middle of polypeptides to produce shorter polypeptides & dipeptides.
• Where do endopeptidases work?

  In the stomach & ileum
• Why are shorter molecules better for digestion?

  There are more enzyme binding sites for faster hydrolysis
• What is the role of exopeptidase in the digestion of proteins?

  Exopeptidase hydrolyses peptide bonds at the ends of the polypeptide to produce dipeptides or individual amino acids.
• Where do exopeptidases work?

  Only in the ileum
• What hydrolyses the peptide bond in dipeptides?

  Membrane-bound dipeptidases hydrolyse peptide bond in dipeptides to form amino acids.
• Why are membrane-bound enzymes better for increasing the rate of diffusion?

  • Leads to faster hydrolysis -> because the enzyme is orientated in the membrane correctly & more ES complexes can form due to more successful collisions
  • Leads to faster absorption -> there is shorter distances for molecules to travel
• Where are proteins digested in the body?

  Stomach -> duodenum -> ileum
• What do endopeptidases do?

  • Break peptide bonds between amino acids in the middle of the chain
  • creates more ends for exopeptidases for efficient hydrolysis

  
• What do exopeptidases do?

  • Break peptide bonds between amino acids at the ends of polymer chain

  
• What do membrane-bound dipeptidases do?

  Break peptide bond between two amino acids