1st Generation Cephalosporins

• The first-generation cephalosporins act as penicillin G substitutes and are resistant to the staphylococcal penicillinase.
• 1st-generation cephalosporins are effective against

  • Gram + cocci: S. aureus, S. epidermidis, S. pneumonia, S. pyogenes, anaerobic streptococci
  • Gram - rods: E. coli, K. pneumoniae, P. mirabilis
• The suffix "-cef+a" is commonly used to indicate 1st generation cephalosporins.
• 1st generation cephalosporins include

  • cephalothin
  • cefazolin