Lincosamides

• Lincosamides are represented by clindamycin.
• Lincosamides function by binding to the 50S subunit of the ribosome and inhibiting translocation.
• Clindamycin can be given perorally, parenterally, or as a topical cream.
• Clindamycin is used to treat anaerobic bacterial infections of the lungs and mouth.
• The cream form of Clindamycin can also be given to treat acne.
• Common side effects of Clindamycin include

  • GI distress like diarrhea, nausea, vomiting, and cramps.
  •  bacterial superinfection by Clostridium difficile