Oxazolidinones

• Oxazolidinones bind to the 50S subunit of the ribosome.
• Linezolid is the main Oxazolidinones.
• Linezolid can be used parenterally + perorally.
• Linezolid is effective against gram-positive bacteria but is reserved for bacterial infections that are resistant to other antibiotics, such as MRSA + VRE.
• Linezolid side effects include

  •  diarrhea, nausea, vomiting, and rash.
  • bone marrow suppression
  • thrombocytopenia
  • peripheral neuropathy
  •  optic neuropathy
• Linezolid is a weak inhibitor of monoamine oxidase, and those taking antidepressants can develop serotonin syndrome which is characterized by

  • flushing,
  • extremely high body temperature,
  • muscle rigidity,
  • tremor that may progress to seizures.