Rifampin

• Rifampin can be administered orally or parenterally and acts by inhibiting mycobacterial RNA polymerase, and therefore, the synthesis of RNA.
• Rifampin can get into urine, saliva, tears, feces and sweat, which turns them orange!
• Side effects of rifampin include

  • hepatitis
  • rash
  • fever
  • GIT problems -> abdominal pain, diarrhea, nausea, and vomiting
• Rifampin is a strong CYP450 enzyme inducer.