Calcium Channel Blocker

• Calcium Channel Blockers:

  • examples include: amlodipine, felodipine, nifedipine, diltiazem, verapamil etc
  • These drugs act directly on the calcium channels on the sarcolemma of the ventricular cardiomyocytes to partially block these channels and decrease calcium influx on depolarisation
  • Decreasing calcium influx either by using beta blockers or calcium channel blockers has exactly the same effect on force generation and stroke volume