Hydroxychloroquine

• What is hydroxychloroquine?

  DMARD
• What is the pharmacology of hydroxychloroquine?

  Target: TLR9 & 7

  Action: Antagonist
• What are the indications of hydroxychloroquine?

  Acute rheumatoid arthritis

  SLE
• What are the side effects of hydroxychloroquine?

  Diarrhoea

  Nausea

  Skin reactions
• MOA - Hydroxychloroquine

  Exact mechanism unknown

  Accumulates in human organelles -> increases pH -> prevents alpha & beta chains of MHC II from dimerising -> inhibits antigen presentation -> decreases inflammatory response & decreases release of cytokines (IL-1 & TNF)