Sulfalazine

• What is sulfalazine?

  DMARD
• What is the pharmacology of sulfalazine?

  Target: COX-1 & COX-2

  Action: Antagonist

  Target: Phospholipase A2

  Action: Antagonist
• What are the indications of sulfalazine?

  Crohns

  Ulcerative colitis

  Rheumatoid arthritis
• What are the side effects of sulfalazine?

  Diarrhoea

  Fever

  Nausea
• MOA- Sulfalazine

  Exact mechanism unknown

  Sulfalazine blocks COX & lipoxygenase pathway -> decreased prostaglandins & leukotrienes -> reduced inflammation