Non-Hodgkin's

• What sex is NHL more common in?

  Males
• What are some possible risk factors for developing NHL?

  HIV

  Immunosuppression

  Infections

  Autoimmune diseases
• Is low-grade NHL curable once advanced?

  No
• What is the most common type of indolent NHL?

  Follicular lymphoma
• What is the most common type of aggressive NHL?

  Diffuse large B-cell lymphoma
• How may a patient present with NHL?

  Painless lymphadenopathy
• Which lymph nodes are commonly involved with NHL?

  Cervical

  Axillary

  Inguinal

  Femoral
• What are the most common extranodal sites of involvement for NHL?

  GI

  Skin

  Bone marrow
• What are some symptoms caused by enlarging nodes leading to mass effect?

  SOB - compression of SVC

  Jaundice - compression of biliary tree

  Vomiting and constipation - Bowel obstruction
• What are some manifestations of specific NHL presentations?

  Mycosis fungoides = skin lesions

  Burkitt's lymphoma = bowel obstruction

  Lymphoblastic lymphoma
• What blood tests are done for NHL?

  FBC

  U&Es

  LFTs
• What is some imaging done for NHL?

  CXR - mediastinal adenopathy

  MRI brain/spinal cord (if neuro symptoms are present)
• What are some specific diagnostic tests for NHL?

  Biopsy

  FISH - identify MYC rearrangement (Burkitt's lymphoma)
• What is some imaging used to stage NHL?

  CT chest abdo pelvis or PET
• How is NHL staged?

  Same as Hodgkin's