Enzymes increase the rate of reaction by lowering the activation energy of the reaction they catalyse.
Active site is the area of the enzyme where the reaction with the substrate takes place.
Enzymes are specific to substrates they bind to meaning that only one type of substrate fits into the active site of the enzyme
When the enzyme and substrate form a complex, the structure of the enzyme is altered so that the active site of the enzyme fits around the substrate. This is called the induced fit model.