Enzymes

• Metabolism

  • Rate of chemical reactions in the body
• Enzymes


  • Biological catalysts
  • Globular tertiary proteins
  • Speeds up rate of reaction
  • Increases rate of reaction
  • Provides route with lower activation energy
• Enzyme substrate complex

  • The bond between an enzyme's active site and it's complementary substrate
• Induced-fit


  • When an enzyme's active site undergoes a conformational change to be complementary to a substrate and form enzyme substrate complexes
• Temperature

  • Low temperature, less energy, less frequent successful collisions of enzyme to substrate, less enzyme substrate complexes
  • High temperature, high energy, bonds break, protein's tertiary structure changes, active site denatures, no longer form enzyme substrate complex
  • Optimum temperature, more activation energy, more frequent successful collisions of enzyme to substrate, more enzyme substrate complexes
• pH


  • Changes in pH change the hydrogen ion concentration
  • May interfere with charges on the amino acids
  • Change in tertiary structure
  • Denatures active site
  • Less enzyme substrate complexex