non-neoplastic myeloid disease

• Aplastic anemia is the failure of myeloid cell production and multiple cell lines may be depleted (pancytopenia - when multiple lines are affected). It is usually secondary in origin due to either…

  • Toxicity
  • Adverse drug reaction
  • Infection — Ehrlichia, parvovirus, feline leukemia virus)
• The low platelets create clotting issues, the low neutrophils means there is a reduced immune system which means the animal is susceptible to spontaneous infections. Low erythrocytes leads to anemia.

  • May need prophylactic antibiotics to support the immune system until neutrophil levels increase

  Neutrophils are the first cell to decrease in pancytopenia and hence spontaneous infections are likely to be one of the earlier signs.
• what is the circulating lifespan of platelets in a dog?

  5 to 7 days
• In these cases we can perform haematology but a bone marrow aspirate may be essential for diagnosis.
• what is the circulating lifespan of neutrophils in a dog?

  4 to 8 hours
• what is the circulating lifespan of erythrocytes in the dog?

  110 to 120 days
• how long does it take a dog to produce neutrophils?

  6 days
• how long does it take a dog to produce platelets?

  12 days