genetic explanation

• OCD is a polygenic condition- two genes are implicated- the SERT and COMT genes, A mutated SERT gene leads to increased reuptake of serotonin leaves low levels of serotonin in the synapses of OCD patients
• A mutated COMT gene leads to decreased leads to decreased reuptake of dopamine which leaves high levels of dopamine in the synapses of OCD patients
• the SERT gene affecting serotonin transport and potentially leading to lower levels, and the COMT gene impacting dopamine levels and clearing,
• the SERT gene is responsible for the reuptake of serotonin, a neurotransmitter involved in mood regulation, OCD LINK- variations in the SERT gene can lead to lower serotonin levels, which have been implicated in OCD
• high levels of dopamine in the striatum have been associated with increased compulsive reward-seeking behaviours which could be a factor in OCD