Radioimmunotherapy

• What is radioimmunotherapy?

  combination of radiation therapy and immunotherapy used to treat non-Hodgkin lymphoma and other types of cancer; uses monoclonal antibodies paired with radioactive materials called radiotracers.
• types of binding of radionuclide to monoclonal antibody?

  1. Direct incorporation into antibody molecule (Bexxar)
  2. Chelate binding using a carrier (thiuxetan) that utilizes covalent binding to the antibody (Zevalin).
  3. Immune binding by a hapten that contains a radionuclide to the second active site of the antibody
• what are the indications for Radioimmunotherapy 90Y-ANTI-CD20?

  treatment of non-Hodgkin lymphomas
• what Rf is used in radioimmunotherapy 90Y-ANTI-CD20?

  • Iodine-131-Bexxar,
  • Yttrium-90-Zevalin,
  • Rituxan
• what is the procedure of radioimmunotherpay 90Y-ANTI-CD20?

  Whole body scan is done after administration of RF to confirm the intensity of binding in the tumor
• Adverse effects of radioimmunotherapy 90Y-ANTI-CD20 are immune response, transient reduction of blood cells.