combination of radiation therapy and immunotherapy used to treat non-Hodgkin lymphoma and other types of cancer; uses monoclonal antibodies paired with radioactive materials called radiotracers.
types of binding of radionuclide to monoclonal antibody?
Direct incorporation into antibody molecule (Bexxar)
Chelate binding using a carrier (thiuxetan) that utilizes covalent binding to the antibody (Zevalin).
Immune binding by a hapten that contains a radionuclide to the second active site of the antibody
what are the indications for Radioimmunotherapy 90Y-ANTI-CD20?
treatment of non-Hodgkin lymphomas
what Rf is used in radioimmunotherapy 90Y-ANTI-CD20?
Iodine-131-Bexxar,
Yttrium-90-Zevalin,
Rituxan
what is the procedure of radioimmunotherpay 90Y-ANTI-CD20?
Whole body scan is done after administration of RF to confirm the intensity of binding in the tumor
Adverse effects of radioimmunotherapy 90Y-ANTI-CD20 are immune response, transient reduction of blood cells.
