Prostate Cancer

• What imaging do we use for diagnosis of prostate cancer?

  • 68Gallium-PSMA
  • Lymphoscintigraphy
  • Immunoscintigraphy
  • Prostate specific antigen (PSA) blood test
  • PET/CT with 68Ga-PSMA
  • Digital rectal examination
• What imaging do we use for the treatment of prostate cancer?

  • Molecular Radiotherapy with 177Lu-PSMA
  • Hormonal Therapy
  • Chemotherapy
  • Immunotherapy
• what is Molecular radiotherapy?

  the delivery of radiation to malignant tissue via the interaction of a RF with molecular sites and receptors
• what Rf is used in molecular radiotherapy?

  177Lu-PSMA
• 177Lu – PSMA description

  • IV administration
  • beta emission
  • Damage small tumors while preserving the tissue surrounding them
  • 2mm tissue penetration
  • 6.7 days half-life
• Indication criteria for molecular radiotherapy with 177Lu – PSMA?

  • Medical history report from the referring physician containing a summary of all previous treatments.
  • Adequate anatomical imaging (ex. CT and/or MRI not older than 3 months, preferably less than 2 months.
  • Life expectancy of at least 3-6 months
• Contraindications for molecular radiotherapy with 177Lu – PSMA?

  • Renal impairment
  • Impaired hematological function
  • Severe hepatic impairment
  • Severe cardiac impairment
• Why do we use Gallium for diagnosis and Lu for treatment?

  • Gallium doesn’t emit any radiation process against the cancer cells.
  • Lutetium emits beta radiation that damages cancer cells and, over time, destroys them and minimizes damage to healthy cells.