Candidate Genes

• Combination of some genetic mutations create a vulnerability for OCD

  The genes linked to OCD help to balance mood regulating neurotransmitters in the brain
• Polygenic

  OCD may be caused by many genes

  Potentially 230
• SERT gene

  SERT gene creates a protein that helps to transport serotonin across synapses

  Mutations in SERT gene means this protein isn't made correctly and so can lead to lower levels of serotonin in the brain

  Causing feelings of anxiety / lowered mood
• COMT gene

  COMT creates a protein that helps to clear unused dopamine from the synapse , mutations in this gene can lead to too much dopamine in the brain ( as it is not cleared from the synapse effectively )

  This can lead to feelings of pleasure