Ampicillin

• What is ampicillin?

  Pencillin derivative antibiotic
• What is the pharmacology of ampicillin?

  Target: Penicillin-binding proteins

  Action: Antagonist
• MOA- Ampicillin

  Binds to PBPs -> stops cross-linking of D-alanine & D-alanine -> no cell wall synthesis

  Without PBPs, bacteria upregulate autolytic enzymes -> unable to build & repair cell wall

  = bacteriocidal action
• What are the indications of ampicillin?

  Various bacterial infections
• What are the side effects of ampicillin?

  Diarrhoea

  Nausea

  Skin reactions